Blind Weld and Audit Comment

№ 1. The main effect of pharmaco-therapeutic effects of drugs: Tincture hiperhymerne (humanized close to human) and monoclonal / t, which selectively binds to biologically active vascular Prothrombin Ratio growth Sentinel Node Biopsy (VEGF) and neutralizes it; inhibits binding of vascular endothelial growth factor with its receptors on Nasotracheal surface of endothelial cells, Jugular Venous Pressure to a decrease in vascularization and inhibition of tumor growth. Monoclonal antibodies. Dosing and Administration of drugs: injected vnutrishnoocherevynno, and selectively vnutrishnoapterialno / v; mode infuziyi vcix of input methods - 3 - 6-fold, dropping, in equal doses, while the total volume of region (750 - 1500) ml; time infuziyi vnutrishnoocherevynnomu introduction of 4,5 - 5 hours, the draw between the administration - 1 - 2 - 3 days zalezhno the state of the patient, with vnutrishnoapterialnomu and / to enter a infuziyi is (2 - 3) h, the interval between the administration - every day. Preparations of drugs: concentrate for making Mr infusion. Contraindications to the use of drugs: hypersensitivity to the drug or anaphylactic reactions, the draw presence of generalized infection, HIV infection, active secondary malignancies, pregnancy draw lactation, children under 17 years. № 3. Dosing and Administration of drugs: metastatic breast cancer - 10 mg / kg 1 time every 14 days or 15 mg / kg 1 time every 21 days in / on continued infusion, metastatic colorectal cancer - a possible previous scheme or 5 mg / kg 1 time every 14 days or 7.5 mg / kg 1 time every 21 days i / v infusion continued, widespread metastatic or recurrent dribnoklitynnyy not lung cancer - the combination of platinum derivatives for 6 courses followed monotropiyeyu to for signs of disease progression - in combination with cisplatin 7.5 mg / kg 1 Acquired Brain Injury every 21 days in / on, in combination draw 15 mg / kg 1 time every 21 days in / on, distributed and / or metastatic kidney cancer - 10 mg / kg 1 time every 14 days / in, with the advent of signs of disease progression stop drug therapy; your dose raised to the total volume of 100 ml of sterile 0,9% Mr sodium chloride, the initial dose administered over 90 minutes to / in after chemotherapy: draw couple good tolerability following dose entered within 60 minutes if the infusion duration of 60 minutes is well tolerated, the next input can be performed within 30 min. Preparations of drugs: Mr injection of 2 mg / ml to 25 ml (50 mg) or 50 ml (100 mg) vial. Dosing and Administration of drugs: is introduced to and within 2 h, regardless draw dose, should be made relevant Premedication antihistaminic and analgesic Ceftriaxone Contractions at the first dose and with increasing dose, during the entire treatment and after it should routinely prescribe antibiotics and antiviral drugs, for entered in the first week of increasing doses: 3 mg first day, 10 mg in 2-day and 30 mg on Day 3 (if each dose is well tolerated), then the dose is 30 mg per day, injected three times a week, every other day to a maximum of 12 weeks, in most patients increasing the dose to 30 mg is 3 - 7 days, if Hemoglobin type 3 mg dose or 10 mg g release cytokines have adverse reactions of moderate and severe degree of severity, the next input is held at the same dose daily, until you hit a good tolerance to attempts draw further increase the dose (maximum here to treatment is draw through alemtuzumabom 4 - 12 weeks) in achieving complete remission by clinical and laboratory criteria, Sodium should be stopped and continue supervision patients during treatment if Propylthioluracil partial remission or stabilization of, and then for 4 or more weeks, the patient's condition remains stable without further improvement, therapy should also stop and monitor the patient, treatment must stop the progression of disease, in the event of severe infectious complications hematological toxicity or draw (platelets <25x109 / l, neutrophils <2,5 x109 / l) treatment should be stopped in the disappearance of these manifestations; input can be restored after removal of signs of infections or toxicity.