Indications for use drugs: treatment of opioid dependency treatment with th pain of high intensity (after surgery in cancer patients, burns, MI, renal colic). Indications for use drugs: pain c-m of different origin: head, toothache, neuralgia, sciatica, myositis, pain during menstruation as an adjuvant can be used watermarking pain relief after surgical watermarking diagnostic interventions; hipertermichnyy s-m watermarking . Indications for use drugs: pain c-m strong and medium intensity of different origin (post-operative period, MI, gynecological intervention, anesthesia delivery, watermarking neoplasm) as an additional means of anesthesia during general anesthesia. Pharmacotherapeutic group: N02AF02-opioid analgesics. Pharmacotherapeutic group: N07BC01 - tools that are used for opiate addiction. Side effects and complications in the use of drugs: drowsiness, nausea and / or vomiting, sweating / dry skin, asthenia / somnolence, headache, feeling hot, dry mouth, confusion, feeling of lightness / euphoria, dizziness, dreams, anxiety, depression, anxiety, dysarthria, dysforiya, hallucinations, paresis, feeling cold, euphoria, nervousness, increase / decrease blood pressure, tachycardia, palpitations, diplopia, rash / nettles Kostyanko, myalgia, slow breathing, airway obstruction, shallow breathing, drug abuse and dependence (a much smaller potential for the development of habituation in comparison with morphine). sublingual absorption of 0.4 mg, 2 mg, 8 mg. Dosing and Administration of drugs: prescribed only in special centers and clinics for treatment under medical supervision, medication used sublingual and held in the watermarking until dissolved tab.; Table. The main pharmaco-therapeutic effects: pain reliever, antipyretic and anti-inflammatory action, analgesic effect is caused by inhibition of COX and blocking synthesis of prostaglandins from arachidonic acid involved in the formation of pain reactions (bradykinin, prostaglandins, etc.) slowing of extra-and proprioceptive pain impulses in the CNS, increase the threshold of excitability talamichnyh centers pain sensitivity and reduced response of brain structures responsible for pain perception to external stimuli; antipyretic effect due to reduced formation and release of neutrophils substances that affect teploproduktsiyu; inflammatory effects associated with inhibition of prostaglandin synthesis. Indications for use of drugs: symptomatic treatment of moderate and severe pain, Immunoglobulin M pain in the postoperative period for analgesia in maxillofacial surgery Standard Deviation migraine, for sedation before surgery or anesthesia as a supplement to balanced anesthesia and analgesia for childbirth. Method of production of drugs: Mr injection of 2% to 1 ml in amp. Contraindications to the use of drugs: inhibition of respiratory failure due to respiratory center, general exhaustion, abdominal pain unclear etiology (before diagnosis), H. Side effects and Chronic Mountain Sickness in the use of drugs: sedative nature of reaction, sweating, nausea, vomiting, dizziness, dry mouth and headache, injection site - local pain, swelling, redness, and burning sensation of heat, increase or decrease blood pressure, bradycardia, tahikardyiyu, nettle watermarking difficulty speaking, lack of clarity of vision and hot flashes, neurotic reactions, depression, confusion and dysforiya.
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